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Surgical Innovation
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Article

Operative Time and Other Outcomes of the Electrothermal Bipolar Vessel Sealing System (LigaSureTM) Versus Other Methods for Surgical Hemostasis: A Meta-Analysis

Alex Macario*, Franklin Dexter, Jennifer Sypal, Ned Cosgriff, and B. Todd Heniford

* To whom correspondence should be addressed. E-mail: amaca{at}stanford.edu.


  Abstract
A meta-analysis was performed of 29 prospective, randomized trials (published January 1, 2000, to August 14, 2007) comparing an electrothermal bipolar vessel sealing system (EBVS-LigaSureTM, Covidien) (total n = 1107 patients) with either clamping with suture ligation/ electrocauterization (n = 1079 patients) or ultrasonic energy (eg, Harmonic Scalpel®, Johnson & Johnson). Hemorrhoidectomy (12 articles), hysterectomy (4 articles), and thyroidectomy (3 articles) were the most common procedures. For 15 of 26 studies reporting standard deviations, the normalized mean operative time reduction for EBVS equaled 28% (95% confidence interval [CI] 18%-39%, P < .0001) compared with conventional surgical hemostasis. Operative time was reduced with EBVS in 24 of 26 studies (P < .0001). EBVS was associated with 43 mL (95% CI 14-73 mL, P = .0021) less blood loss, fewer complications (odds ratio 0.66, 95% CI 0.47-0.92, P = .02), and mean reduction in postoperative pain of 2.8 units (95% CI 1.5-4.1, P < .0001). Five studies used ultrasonic energy as the comparator, but none reported standard deviation so data could not be pooled.

First published on October 22, 2008, doi:10.1177/1553350608324933

Surgical Innovation 2008;15:284.

A more recent version of this article appeared on December 1, 2008

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