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Association of Demographic and Treatment Variables in Long-Term Colon Cancer Survival

Department of General Surgery, Carolinas Medical Center, Charlotte, North Carolina

Ronald F. Sing, DO

Department of General Surgery, Carolinas Medical Center, Charlotte, North Carolina

Kent W. Kercher, MD

Department of General Surgery, Carolinas Medical Center, Charlotte, North Carolina

Andrew Stewart, MS

Department of General Surgery, Carolinas Medical Center, Charlotte, North Carolina, American College of Surgeons Commission on Cancer and the Colorectal Disease Site Team, Chicago, Illinois

Bradley L. Demeter

Department of General Surgery, Carolinas Medical Center, Charlotte, North Carolina

William W. Hope, MD

Department of General Surgery, Carolinas Medical Center, Charlotte, North Carolina

Nicholas P. Lang, MD

Department of Surgery, Central Arkansas Veterans Healthcare System/University of Arkansas for Medical Sciences, Little Rock, Arkansas

Greene, MD

Department of General Surgery, Carolinas Medical Center, Charlotte, North Carolina

B. Todd Heniford, MD

Department of General Surgery, Carolinas Medical Center, Charlotte, North Carolina, todd.heniford{at}carolinashealthcare.org

The purpose of this study is to examine demographic and treatment variables because they relate to 5-year survival in colon cancer. The study design is analysis of 174 471 patients with colon and rectosigmoid cancer as reported to the American College of Surgeons National Cancer Data Base. Factors associated with a reduced risk of mortality included female gender (hazard ratio = 0.89; 95% confidence interval, 0.87-0.90), education status (hazard ratio = 0.87; 95% confidence interval, 0.85-0.89), increased number of lymph nodes resected (compared with <8, 8-12: hazard ratio = 0.90; 95% confidence interval, 0.89-0.92; >12: hazard ratio = 0.79; 95% confidence interval, 0.77-0.80), and addition of chemotherapy (hazard ratio = 0.69; 95% CI, 0.68-0.71). African American race (hazard ratio = 1.14; 95% confidence interval, 1.11-1.18) and increasing age correlated with an increased hazard risk (61-75 years: hazard ratio = 1.26; 95% confidence interval, 1.23-1.29; 76 years: hazard ratio = 2.15; 95% confidence interval, 2.09-2.21, compared with age <60 years). Survival in colon cancer is significantly impacted by patient's age, race, gender, and education status but not by income or area of residence.

Key Words: colon cancer • demographics • survival • lymph node • adjuvant therapy

This version was published on March 1, 2008

Surgical Innovation, Vol. 15, No. 1, 17-25 (2008)
DOI: 10.1177/1553350608315955


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