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Surgical Innovation, Vol. 13, No. 2, 102-108 (2006)
DOI: 10.1177/1553350606291337

The Effect of Octreotide on Pancreatic Damage in TNBS-Induced Colitis

Siraç Akgül, MD

Department of General Surgery Instanbul Medical Faculty, Istanbul University, Instanbul, Turkey

Yesim Erbil

Department of General Surgery, Istanbul University, Instanbul, Turkey, yerbil2003{at}yahoo.com

Murat Giris, MSc

Istanbul University, Instanbul, Turkey

Halil Alis, MD

Department of General Surgery, Istanbul University, Instanbul, Turkey

Burcu Tulumoglu Yanik, MD

Department of General Surgery, Istanbul University, Instanbul, Turkey

Vakur Olgaç, PhD

Istanbul University, Instanbul, Turkey

Gülçin Aykaç Toker

Istanbul University, Instanbul, Turkey

Inflammatory bowel disease, a chronic condition of the intestine, is associated with numerous extraintestinal manifestations, including pancreatitis. This study investigated the effect of octreotide administration on oxidative damage in a rat model of colitis induced by 2,4,6-trini-trobenzene sulfonic (TNBS) acid. Colonic and pancreatic malondialdehyde and glutathione levels are indicators of oxidative damage, and TNBS-induced colitis significantly increased the colonic and pancreatic malondialdehyde levels and decreased glutathione levels. Octreotide treatment was associated with decreased malondialdehyde levels and increased glutathione levels in the colonic and pancreatic tissue. The colonic mucosal structure was preserved and pancreatic inflammation decreased in rats treated with octreotide. Octreotide also significantly decreased nuclear factor-kB expression by immunohisto-chemistry in the colonic and pancreatic tissue compared with TNBS-induced colitis group. Octreotide appears to have protective effects against TNBS-induced colonic and pancreatic damage. These results imply the reduction in mucosal damage owing to the anti-inflammatory and antioxidant effects of octreotide.

Key Words: octreotide • TNBS-induced colitis • pancreatitis


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