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Surgical Innovation, Vol. 12, No. 3, 227-231 (2005)
DOI: 10.1177/155335060501200307

Small Intestinal Submucosa Intracardiac Patch: An Experimental Study

Michael Rosen, MD

Cleveland Clinic Foundation Departments of General Surgery, Cleveland, OH

Eric E. Roselli, MD

Cleveland Clinic Foundation Departments of Thoracic and Cardiovascular Surgery; 9500 Euclid Avenue, H35, Cleveland, OH 44195 roselle{at}ccf.org

Cristiano Faber, MD

Cleveland Clinic Foundation Departments of Thoracic and Cardiovascular Surgery, Cleveland, OH

Norman B. Ratliff, MD

Cleveland Clinic Foundation Departments of Anatomic Pathology, Cleveland, OH

Jeffrey L. Ponsky, MD

Cleveland Clinic Foundation Departments of University Hospitals of Cleveland Department of Surgery, Cleveland, OH

Nicholas G. Smedira, MD

Cleveland Clinic Foundation Departments of Thoracic and Cardiovascular Surgery, Cleveland, OH

In this experimental study, small intestinal submucosa was implanted as an atrial prosthesis in calves. Echocardiography and histology showed this to be an impermeable prosthesis that develops a neointimal nonthrombogenic surface making it safe for repair of defects in a low-pressure system. Further study with small intestinal submucosa in an intracardiac position is warranted.

Key Words: small intestinal submucosa • atrial prothesis • neointimal nonthrombogenic surface


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